ea0079001 | Abstracts | BES2021
Bastiaan Maes
, Farzaneh Fayazpour
, Leen Catrysse
, Guillaume Lornet
, De Velde Evelien Van
, Caroline De Wolf
, Sofie De Prijck
, Justine Van Moorleghem
, Manon Vanheerswynghels
, Kim Deswarte
, Benedicte Descamps
, Christian Vanhove
, Hamida Hammad
, Sophie Janssens
, Bart N Lambrecht
Aim: Healthy adipose tissue contains numerous innate and adaptive immune cells that carry a type 2 cytokine immune signature, controlled by IL-33 and reflected by accumulation of ST2+ T regulatory cells (Tregs), type 2 innate lymphoid cells (ILC2s), and alternatively activated macrophages. These type 2 responses are lost in mice or humans on high-caloric diets that lead to obesity. Understanding how type 2 immunity is regulated in adipose tissue could contribute to ...